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Across 2. hepatic impairment, pregnancy, nursing mothers, children 5. atrial fibrillation or preexisting hypertension 7. hypersensitivity, hepatic or renal impairment, cardiomegaly, CHF controlled by digitalis and diuretics, diabetes 9. toxicity potentiated by an MI and with hypokalemia, hypocalcemia, advanced heart disease 10. CHF(especially with beta-blockers) conduction abnormalities, renal or hepatic impairment, the elderly, and nursing mothers 11. Hepatic impairment,elderly, pregnancy, nursing mothers, head injuries, alcohol and drug dependency and physical dependency 12. Breast Cancer, children with acute illness 13. Occlusive vascular disease, cold injury, arterial embolism. ensure adequate fluid resuscitaion of the hypovolemic patient

Down 1. renal impairment, digitalized patients, CNS depressant, or neuromuscular blocking agent 3. Elderly, cardiovascular disease, or hypertension 4. COPD, and very prolonged administration of high concentration in the newborn 6. hypotension, cardiac enlargement, CHF, AMI, ventricular dysrhythmias from digitalis, hepatic or renal impairment 8. hepatic and renal impairment, MI with coronary artery occlusion, or myocardial stenosis