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Across 3. when the red cells are broken down outside of the reticuloepithelial system 4. drug treatment for hereditary spherocytosis 8. autosomal dominant disorder 9. if faulty, these can cause mechanical trauma to RBC's and thus haemolysis 10. caused by failure of spectrin to form hetero-tetramers in the cell membrane 11. sickel cell,hereditary spherocytosis or elliptocytosis are examples of these types of anaemia 12. describes the process of antibody production against self 14. a parasitic infection that can cause haemolysis 15. this element can cause acute haemolytic anaemia also known as Wilson's Disease 16. a feature of increased erythropoeisis 17. can be caused by transfusion reactions and rhesus disease of the newborn

Down 1. these are characterized by a positive Coombs' test 2. burns can cause many of these thorn-shaped red cells to be present in the blood 5. autoimmune haemolytic aneamia that reacts more at 4°C than 37°C. 6. caused by red cells being crushed between the small bones of the feet 7. a deficiency that is a rare autosomal recessive condition that produces rigid erythrocytes due to a lack of ATP 13. abbreviation of a deficiency that reacts to fava beans and is most prevalent in Mediterraneans