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Lecture 7

DISCLAIMER: The author of this puzzle denies responsibility for unsatisfactory exam performance sustained from studying this.

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Across
3.This system is active during 'idling' mental activity.
4.Tau aggregates to form this structure inside neurons.
6.This type of precursor protein is cleaved to form AB40 or AB42.
7.AB42 aggregates to form this structure often outside neurons.
8.This greek letter represents the type of secretase that cleaves APP irregardless of whether it forms AP40 or AP42.
Down
1.Targeting AB42 in this type of cellular environment has been unsuccessful.
2.In Alzheimer's disease, this oligomer unbinds from the microtubules in neurons.
5.The expression of this is enhanced by mental and physical activity.

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