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Across 1. This vitamin helps in preventing cellular damage from free radicals 4. Found predominatly in the cells of the liver, spleen, and bone marrow 7. B2 8. Na, K, Cl, Ca, P, Fe, and Mg are what type of minerals in our body? 9. An increased serum iron and TIBC 10. Heme is directly absorbed because its Fe is in what state? 11. 2 alpha 2 beta chains 13. In a water environment the have an ionic charge 14. Approximately 70-85% of carbon dioxide is processed as bicarbonate 15. Promotes blood clotting 16. Essential for the synthesis and maintenance of collagen 17. what HB changes after age 3? 18. B1 21. Most common anemia in the U.S. 23. Protein portion of a molecule 26. B9 27. Present in the human body in very limited amounts 30. Normally Fe is absorbed about 1-2 mg each day where? 34. Hb assists in maintaining the what in blood? 37. B3 39. A green pigmented compound 43. Lack of this Vitamin will give you Rickets 47. Where is Iron incorporated into HB? 48. What is reffered to a decreased hemoglobin content in RBCs? 49. 20-40mg of Fe are lost in what cycle? 50. B6

Down 1. The Fe binding states are normally 15-50% saturated depending on the gender 2. 2 alpha 2 delta chains 3. High Ferritin, High Apoferritin, Low Transferrin is indications of Fe? 4. CHO on terminal valine on B chain 5. An Fe-loading disorder causing an over-accumulation of Fe 6. Protoporphyrin IX ring 11. Progressive increase in Fe absorption and storage 12. Hemoglobin S 14. 200 time greater affinity for CO than O 19. oxygen binding protein of striated and cardiac muscle 20. What is the enzyme is used in the final step to make Heme? 22. What binds reversibly with Oxygen and aids in electron transport? 24. Hb reversibly transports O2 from the lungs to the tissues of the body is called? 25. Vitamin of Bone growth 28. Spherical molecule consisting of an apotransferritin shell 29. B12 31. Apotransferrin Fe3 complex is called? 32. Found in all nucleated cells in the body 33. Blue People have this 35. Enlarged spleen, to requiring blood transfusions if needed 36. What engulfs RBC to release Fe? 38. What is the enzyme catalyzes the initial step in porphyrin synthesis? 40. What is a degradation product of heme? 41. these cells have the largest concentration of iron in the body 42. Vitamin that helps infections 44. Bone marrow, Spleen and other tissues stores 2/3 of Fe where is the other 1/3 stored? 45. After crossing the membrane of the intestinal cell, ferrous is converted to? 46. Low Ferritin, Low Apoferritin, High Transferrin/Apotransferrin indicates what?