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Learn Pharmacology Through Puzzles (THE SECOND ONE)

Anwar Hamdi, M.D., Ph.D.

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Across
7.a route of administration where absorption is often erratic and incomplete
13.is calculated by dividing the dose that ultimately gets into the systemic circulation by the plasma concentration at time zero
15.The driving force for absorption of a drug is the concentration gradient across a membrane separating two body compartments
18.A constant amount of drug is metabolized per unit of time, and the rate of elimination is constant and does not depend on the drug concentration
19.absorption of drugs which does not require energy, can be saturated, and may be inhibited by compounds that compete for the carrier
20.a route of administration suitable if drug volume is moderate and suitable for oily vehicles and certain irritating substances
Down
1.When two related drug preparations show comparable bioavailability and similar times to achieve peak blood concentrations
2.This mode of drug entry involves specific carrier proteins that span the membrane and it is capable of moving drugs against a concentration gradient, from a region of low drug concentration to one of higher drug concentration
3.is a superfamily of heme-containing isozymes that are located in most cells but are primarily found in the liver and GI tract
4.name given to exogenous substances
5.absorption of drugs which does not involve a carrier, is not saturable, and shows a low structural specificity
6.is a useful pharmacokinetic parameter for calculating a drug’s loading dose
8.is determined by comparing plasma levels of a drug after a particular route of administration with plasma drug levels achieved by IV injection
9.is the fraction of administered drug that reaches the systemic circulation
10.This process limits the efficacy of many drugs when taken orally
11.a route of administration suitable for slow-release drugs and ideal for some poorly soluble suspensions
12.severely reduces blood flow to cutaneous tissues, thereby minimizing the absorption from SC administration
14.transporter protein responsible in the intestines for transporting drugs into the intestinal lumen and reducing drug absorption into the blood
16.reactions most frequently involved in drug metabolism are catalyzed by the cytochrome P450 system (also called microsomal mixed-function oxidases)
17.reactions in metabolism that convert lipophilic molecules into more polar molecules by introducing or unmasking a polar functional group, such as –OH or –NH2

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