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Learn Pharmacology Through Puzzles (1)

Anwar Hamdi, M.D., Ph.D.

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Across
3.When two related drug preparations show comparable bioavailability and similar times to achieve peak blood concentrations
5.can be given to a patient presenting with phenobarbital overdose to alkalinize the urine and keeps the drug ionized, thereby decreasing its reabsorption
8.an antituberculosis drug significantly decreases the plasma concentrations of human immunodeficiency virus (HIV) protease inhibitors thereby diminishing their ability to suppress HIV virion maturation
13.severely reduces blood flow to cutaneous tissues, thereby minimizing the absorption from SC administration
14.Its rate is normally about 20 percent of the renal plasma flow
15.substances that act on living systems at the chemical level
Down
1.is a useful pharmacokinetic parameter for calculating a drug’s loading dose
2.a route of administration where absorption is often erratic and incomplete
4.absorption of drugs which does not involve a carrier, is not saturable, and shows a low structural specificity
6.is the fraction of administered drug that reaches the systemic circulation Bioavailability
7.the actions of the body on the drug
9.the point at which the amount of drug being administered equals the amount being eliminated, such that the plasma and tissue levels remain constant in the case of IV administration and fluctuate around a mean in the case of oral fixed dosage
10.a physical process by which a weak acid becomes less water soluble and more lipid soluble at low Ph
11.hormone working through membrane-spanning enzymes
12.reactions most frequently involved in drug metabolism are catalyzed by the cytochrome P450 system (also called microsomal mixed-function oxidases

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