1									2											3
																											4
						5	6						7				8
				9											10																		11
12									13		14								15						16
																					17
									18
																															19
20
											21								22
																											23
						24
																													25
			26
															27
																			28			29
		30				31
																32					33
								34		35
																		36								37
													38			39
			40																	41									42
				43																44
											45																					46
																					47
											48

Across 1. Constant heavy chain domain is the example of _____ 2. It is possible to have different AB causes with the smae: 5. one of the products of a pepsin cleavage 12. Glycoprotein glycosylated in Golgi and ____ 17. Fluid movement most notably of lymph fluid from circulation to tissue 18. what is the function of IgE. 20. what kind of bond are held together in Ig. 21. what is most variable and has the most Ag contact.____ 22. includes disulfide bonds and lost of proline residues for flexiblity 24. Carbohydrates associated w/ ____. 26. what is the structure of IgA 27. which Ig has no protective function.____ 28. enzyme catalyzing conversion for superoxide radical 30. cleaves disulfide bonds 33. antigen binding fragment 34. intracellular vacuole containing ingested particulate material 39. MALT tissue in small intestine 40. only protein allowed in lymph fluid 43. different biological activities, further classification of Ab along the isotypes 44. group of serum and cell membrane proteins that interact with one another and with other molecule of innate and adaptive immunity to carry out key effector functions. 46. IgM have how many Fabs _______ 47. .Lots ___ for more flexibility. 48. Lots of _________ for disulfides.

Down 1. cytokine that activates cytotoxic Tcell 3. what is the structure of IgE 4. Involved in polymerization of subunits of Ig. 6. what require genetic change in lymphocytes for specifity 7. what is the half life of IgM 8. Light chain have 2 form_________ 9. what is the structure of IgM ______ 10. made by different alleles in individuals, found in constant regions of HC or LC. 11. antigen presenting cell 13. This increase the chance of functional Ab being made. _______ 14. secretes choleragon, binds to epithelial lining of gut, can cause dehydration. 15. what cause an decrease number of Fab binding Ag. 16. heavy chain and light chain have _____. 19. fixed macrophage in the liver 23. secreted proteins that regulate the intensity and duration of the immune response by exerting a variety of effects on lymphocytes. 25. proteolytic cleavage used on IgG 26. What comprise hypervariable region. 29. where the bacteria is digested 31. what has the shortest 1/2 life of in serum ______ 32. agent of precipitation 35. Ab that have small AA difference but express no difference between binding 36. products of chemical precipitation 37. glycoprotein cytokines produced by certain cells that induce an antiviral state in other cells and also help to regulate immune response 38. Keratinocytes in epidermis produce 41. complex of genes encoding cell surface that are required for antigen presentation to T cells 42. a self molecule that attracts macrophages 45. Carbohydrates aid in associate with complement proteins for _. 46. IgM peak at how many days