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Across 4. these hormones can pass directly across the cell surface membrane. 5. this hormone is manufactured by beta cells in the pancreas 6. This gland has both endocrine and exocrine functions 10. the region of the adrenal gland responsible for the manufacture and secretion of adrenaline. 11. the enzyme that converts ATP to cAMP inside cells 15. A substance used by the adrenal cortex to make steroid hormones like cortisol. 16. this is a first messenger that is released in response to stress or fear. 17. this is a common second messenger derived from ATP that transmits a signal inside the cell. 18. the process where conversion of glycogen to glucose occurs 19. Liver cells

Down 1. _________ feedback mechanisms regulate the concentration of blood glucose. 2. ________ of Langherans 3. the process of converting glucose to glycogen 6. hormones made or derived from this biological molecule can not pass directly into the target cells. 7. Signals released by the endocrine system. 8. Glands that release hormones directly into the blood. 9. the process of making glucose by conversion of amino acids and fats. 12. These glands do not release hormones. They have a small duct that carries their secretions to another place. 13. cells that possess the specific receptor for a hormones on their cell surface membrane. 14. alpha cells manufacture this hormone in the pancreas