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Across 2. accumulation of calcium salts in a body tissue, normally occurs in the formation of bones 4. a large multinucleate bone cell that absorbs bone tissue during growth and healing 5. amount of steps in endochondral ossification 9. a process in which bones become brittle and fragile from loss of tissue 11. a cell that secretes the matrix for bone formation 13. process of forming cartilage 15. bone disease that makes bones abnormally dense and prone to breakage (fracture) 17. the soft stuff between joints-assists smooth movement 18. the unmineralized organic component of bone 19. a dense layer of vascular connective tissue enveloping the bones except at the surfaces of the joints. 20. the main structural protein found in animal connective tissue

Down 1. an environment or material in which something develops; a surrounding medium or structure 3. takes place in the bones of the skull 6. the rounded end of a long bone 7. developement of bones 8. process in which cartilage is transformed into bone 10. a cell that has secreted the matrix of cartilage and become embedded in it 12. stem cells 14. having a higher osmotic pressure than a particular fluid, typically a body fluid or intracellular fluid. 16. calcium phosphate crystals