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Across 5. antibody-mediated immunity carried out by B cells 8. degradative enzyme, reactive oxygen intermediate 9. agents used to destroy microbes or inhibit their growth within a host 10. usually gained by bacteria by horizontal gene transfer 2 wrds 12. ability of an organism to establish a focal point of infection 13. adverse effect is ototoxicity 15. mobile genetic elements capable of HGT 16. immunity that recognizes, responds to and remembers non self for a better response 17. chemical messengers like histamine 18. chemical defense in tears and perspiration 19. antigen determinant

Down 1. C3a and C5a, chemokines that initiate inflammation and___ 2. commensal microbiota may be opportunistic pathogens if___ 3. discovery of sulfonamides, drugs can be biologically modified by the host 4. skin, mucous membranes, mucus, ciliary escalator of innate immunity 2 wrds 6. broad spectrum inhibitor of cell wall synthesis 7. reduces the number of infectious units to be dealt with 8. formed by B cells, secrete antibodies 11. immunoglobulins are also known as___ 14. opsonization, inflammation, MAC formation