| 49 | | Paul journeys to Rome |
| 48 | | Printed Bibles are available in 28 languages |
| 60 | | Benedict of Nursia destroys pagan temple at Monte Cassino and builds monastery |
| 197 | | Harold I of Denmark converts to Christianity and smooths the way for the acceptance of Christian faith by the Danish people |
| 200 | | The Congo sees its first group of missionaries arrive. Under the ministry of these Franciscan and Dominican priests, the king would soon be baptized and a church built at the royal capital. |
| 327 | | Tertullian writes that Christianity had penetrated all ranks of society in North Aftica |
| 364 | | Roman Emperor Theodosius I makes Christianity the official state religion |
| 381 | | Jerusalem Council on admitting Gentiles into the Church |
| 496 | | Constantinople falls to the Muslim Ottoman Turks who make it their capital. |
| 528 | | Johannes Gutenberg begins printing the Bible with his movable type printing process; Pope Plus II assigns the evangelization of the Portuguese Guinea Coast of Africa to the Franciscans led by Alfonso de Bolano. |
| 596 | | Paul begins his first missionary journey to modern day Turkey |
| 912 | | In the Philippians, Diego de Herrera baptized Chieftain Tupas of Cebu and his son |
| 965 | | The first Jesuit to enter what is now the United States, Pefro Martinez, is clubbed to death by fearful Indians on the sands of Fort George Island, Florida |
| 981 | | Twenty six Japanese Christians are crucified for their faith by General Toyotomi Hideyoshi in Nagasaki, Japan |
| 1266 | | First Christians are reported in Switzerland and Belgium |
| 1382 | | Pope Paul III orders that the Indian of the New World be brought to Christ "by the preaching of the divine word, and with the example of the good life" |
| 1453 | | The Normans become Christian |
| 1462 | | Five Jesuit missionaries- Rudolph Acquaviva, Peter Berno, Francis Aranha, Alphonsus Oacheco and Anthony Francisco-are murdered near Goa |
| 1491 | | Mongol leader Khan sends Marco Polo's father and uncle, Niccolo and Matteo Polo, back to Europe with a request to the Pope to send 100 Christian missionaries |
| 1493 | | Christopher Columbus takes Christian priests with him on his second journey to the New World |
| 1498 | | Conversion of Clovis I, king of Franks in Gaul, along with 3000 warriors |
| 1516 | | Bible translated into English from Latin by John Wycliff |
| 1519 | | Conversion of Vandals to Christianity during the reign of Emperor Valens |
| 1529 | | Two Franciscans accompany Herman Cortes in this expedition to Mexico |
| 1537 | | First Christians are reported in Kenya |
| 1550 | | Nestorian monks visiting China find no traces of Christian community left |
| 1566 | | Gregory the Great sends Augustine and a team of missionaries to England to reintroduce the gospel. The missionaries settle in Canterbury and within a year baptize 10,000 people. |
| 1568 | | Franciscans Peter of Ghent writes from Latin America that he and a colleague had baptized 14,000 people on one day |
| 1583 | | Three Franciscans are killed by cannibals in northeastern South America, in the area of Columbia and Venezuela |
| 1597 | | Emperor Constantine baptized shortly before his death |
