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Across 3. Pis are potent CYP3A4 ____ 6. Abacavir is associated with hypersensitivity reaction and ____ testing is required before starting it 8. Competes with endogenous deoxyribonucleotides fol the catalytic site of reverse transcriptase enzyme 9. Efavirez needs to be taken on ____ stomach 10. ___ binds and inhibits intergase inhibitors 15. Tenofovir is notorious for ____ 17. AIDS is defined when _____ is <200 cell/mm3 18. Fatal hepatic necrosis is associated with 19. Brand name of rilpivirine/tenofovir/emtricitabine 21. ___ prevent the cleavage of polyproteins into mature infectious virous 22. Brand name of elvitegravir/cobicistat/tenofovir/emtricitabine ____ 25. Brand name of abacavir/zidovudine/lamivudine 27. ___ is used to prevent HIV trasmission from bother to fetus during pregnancy 28. Rilpivirine needs to be take on ____ stomach and contraindicated with PPIs 29. ___ used for boosting protease inhibitors but has no efficacy againg virous at boosting dose 30. Atazanavir requires ____ environment to be absorbed 31. Number of active antiretroviral agents from atleast two drug classes recommended as initial antiretroviral therapy (ART)

Down 1. Isentress is ___ dosing 2. Pis are contraindicated with this statin 4. Single mutaion can cause class resistance 5. CDC no longer recommends ___ as confirmatory test. Rather, antibody diferentiation immunoassay is preferred 7. PIs are associated with ___ 11. M184V mutation makes HIV virus more _____ to tenofovir and zidovudine 12. All NNRTIS lose its activity in K103N mutation except ___ 13. All NNRTIs are eleminated via kidneys except ___ 14. ____ quantifies number of copies of HIV RNA in the plasma 16. ___ is a CCR5 antagonist and requires topism assay before initiation 17. Monitor ___ for zidovudine 20. HIV is a _____ 23. ____ is associated with neuropsychiatric effects and teratogenicity 24. In-home HIV Test Kit 25. ___ may be utilized in pre-exposure prophylaxix therapy 26. NNRTIs are CYP3A$ ____