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Across 2. noninvasive examination of _____ _______ allows for easy visualization of structures impacted by hypertension 8. their effectiveness in treating hypertension is related to their ability to cause smooth muscle relaxation 13. ACE inhibitors and ______ can lead to ______ toxicity (same word) 14. are the first line antihypertensives according to the JNC 7 18. ACE inhibitors cardiovascular effects are due to their ability to reduce blood pressure by decreasing _____ ______ _____ 23. Hyperkalamia is much _____ likely to occur with ARBs than ACE inhibitors 25. most commonly the result of another disease 26. this protective effect is because ACE inhibitors ______ glomerular filtration pressure 28. prodrugs most be metabolized to it's active form in the body, generally in the ______ 31. a dry, nonproductive cough is a characteristic of ACE inhibitors, it is _______ when drug is discontinued 34. ACE inhibitors have been shown to decrease morbidity and mortality in patients with _____ ____ 35. patients taking ____ _____ _____ will need to monitor their blood pressure and pulse rate at home 38. can reduce the antihypertensive effect of ACE inhibitors 41. direct acting vasodilators are useful as antihypertensives because of their ability to directly cause peripheral vasodilation which reduces ____ 44. action occurs at the heart and blood vessels 46. a systolic blood pressure of 120-139 mm Hg and/or a diastolic blood pressure of 80-89 mm Hg 47. unlike ACE inhibitors ARBs do not cause this 49. is the most commonly used calcium channel blocker used to treat hypertension 50. The ARBs block the binding of ______ __ to type 1 ______ __ receptors (same words) 51. ACE inhibitors are contraindicated in patients with a baseline _________ level of 5 mEq/L or higher 52. the treatment of hypertension 53. ARBs are associated with lower _____ after MI than ACE inhibitors 54. acute heart failure, MAOIs, severe mental depression, peptic ulcer and severe liver/kidney disease 55. adrenergic drugs can cause ________ CNS depression when taken with alcohol, benzodiazepines, and opiods 56. ______ of vasodilators include hypotension, cerebral edema, head injury, acute MI and coronary artery disease 57. if ______ occurs contact prescriber immediately

Down 1. ______ ______ ______ is a common adverse effect of ARBs along with headache 3. this can happen when alpha 2 receptor agonists can result in this 4. _____ ______ are the most commonly used diuretics for treatment of hypertension 5. _____ _____ that can cause hypertension include Addison's disease, coronary heart disease, Cushing's disease, nicotine use, preeclampsia of pregnancy, renal or liver insufficiency and a stressful lifesyle 6. are similar to ACE inhibitors 7. ____ _____ may occur with antihypertensives, if this occurs the patient has options to help alleviate this problem 9. there are ten of these available for clinical use 10. taking ACE inhibitors taken with potassium supplements and potassium sparking diuretic can lead to 11. ACE inhibitors are ______ ______ ______ in the treatment of both heart failure and hypertension 12. ACE inhibitors can stop the progression of ______ ______ _____ that is sometimes seen after MI 15. use of vasodilating drugs may also be contraindicated in cases of heart failure secondary to ________ 16. cause is unknown and 90% of cases are of this type 17. has many adverse effects including dizziness, headache, orthostatic hypotension, dysrhythmias, sodium and water retention, nausea, vomiting and hyperglycemia in diabetic patients 19. _______ act directly on arteriolar and/or venous smooth muscle to cause relaxation 20. ACE inhibitors have been shown to have a protective effect on the ______ 21. primary therapeutic effect of diuretics is the reduction of plasma and extracellular fluid volumes which results in _______ ______ 22. Calcium channel blockers block the binding of calcium to its receptors which prevents _____ 24. pregnancy and lactation are ________ of ARBs 27. all the vasodican be used to treat _______ either alone or in combination with other drugs 29. action in the brain 30. monitoring of levels of ________ is necessary for all patients taking ARBs and ACE inhibitors 32. ACE inhibitors should not be used by this population unless there is no safer alternative 33. has the shortest half life of the ACE inhibitors 36. a common adverse effect of adrenergic drugs 37. eye exams should be scheduled every __ _____ to evaluate treatment 39. the beneficial hemodynamic effect of ARBs is their ability to decrease ______ 40. this is a potent vascoconstrictor and induces aldosterone secretion by the adrenal glands 42. systemic vascular resistance is a measure of ______ 43. therapeutic effects are ARBs are related to their potent ______ properties 44. Captopril and lisinopril are the only 2 ACE inhibitors that are NOT _______ 45. ARBs affect primarily vascular smooth muscles and the _____ ____ 48. in its topical form can restore hair growth