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Across 1. _____ _____ can reduce the metabolism of calcium channel blockers 5. instruct patients to keep nitrates in their _____ _____ 8. beta blockers _____ myocardial oxygen demands 9. if medication does not _____ then the nitroglycerin has lost its potency 12. ______ ______ is a rapid-acting antianginal dosage form to treat acute anginal attacks 14. most common adverse effect of topical nitrate dosage forms 15. nitrates are contraindicated with use of _____ _____ _____ such as sildenafil, tadalafil and vardenafil 18. blocking of _____ _ ______ may lead to decrease heart rate, cardiac output and contractility 20. nitrates ______ all blood vessels 21. number of main classes to treat angina 24. nitroglycerin is only potent for _ __ _ ______ 26. the blocking of calcium ultimately _____ the oxygen supply to the heart 29. can be triggered by exertion or other stress and other drugs that stimulate the sympathetic nervous system 30. _____ are the main stay in treatment of angina, MI, hypertension, and dysrhythmias 34. a regular nitrate free period is arranged to allow certain _____ _____ to replenish themselves 35. beta blockers taken with diuretics and/or antihypertensives can lead to _____ 36. ______ is an example of the phenylalktlamines class of calcium channel blockers 37. over all goal of antianginal drug therapy is the increase blood flow to ______ ______ and decrease myocardial oxygen demand 38. beta 1 receptors are located in the heart's conduction system and throughout the ______ 39. usually the early stage of progressive coronary artery disease and often ends in an MI in subsequent years 40. beta blockers are most effective in the treatment of ________ angina 41. nitrates have a potential dilating effect on the large and small ______ _____

Down 2. _____ include severe anemia, closed angle glaucoma, hypotension, ans severe head injury 3. calcium channel blockers are considered ____ ____ ____ for angina, hypertension and supraventricular tachycardia due to their acceptable adverse effect and safety profiles 4. diltiazem is an example of the _______ class of calcium channel blockers 5. _____ ______ _____are available in sublingual and oral tablets, capsules, ointments, patches, transligual spray, and IV solutions 6. _______ is an example of the dihydropyridines class of calcium channel blockers 7. beta blockers taken with insulin or other antidiabetic drugs can mask symptoms of _______ 9. blocking of beta 2 receptors may lead to ________ 10. _____ _____ _____ is one of many contraindication of beta blockers 11. by causing venous dilation, nitrates reduce venous return, which reduces preload and results in ____ _____ _____ _____ 13. _____ _____ dosage forms are used for prevention of anginal episodes 16. ______ of calcium channel blockers include acute MI, second or third degree AV block and hypotension 17. results from spasms in the layer of smooth muscle that surrounds atherosclerotic coronary arteries 19. fatty plaque deposits in the arterial walls 22. if this is less than 60 per minute or more than 100 per minute then contact prescriber for further instruction 23. nitrate antianginals can cause additive ________ effects when taken with alcohol, beta blockers, calcium channel blockers, phenothiazines, and ED drugs 25. if after taking _____ tablets symptoms don't resolve within 5 minutes, call 911 immediately 27. is the most common adverse effect of nitrates 28. calcium channel blockers taken with _____ can interfere with drug elemination 31. calcium channel blockers taken with _________ can lead to possible toxicity of both drugs 32. exposure to light, plastic, cotton filler and moisture must be _______ with nitrates 33. the heart needs a large supply of _____ to meed the demands placed on it