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Across 1. Acute issue involving myeloid cell proliferation; mostly white blood cells overloading 5. Most common childhood leukemia 7. Type of count in lab to determine neutrophil levels; good predictor of immune response to infection 10. Method of acquiring sickle cell disease 11. Inherited disorder involving B and T cells communication breakdown leading to neurologic motor dysfunction and vascular lesions 12. Immunodeficiency for which cause cannot be determined readily 15. Cellular feasting 16. Lower dose chemo than induction; designed to eradicate what's left of problematic cells 17. crystalline deposits of uric acid in joints 20. Rheumatic disease with tophi as a key characteristic 21. One type of transfusion complication 22. Platelet daddy 25. Patients with Hodgkin's at high risk for developing these cancers 26. Cause for many of the secondary immunodeficiencies and blood disorders discussed; not medication but the other 27. Overreaction of the body to foreign substance like latex 28. Reed-Sternberg cells noted 31. Steroids, Biologics, Calcineurin inhibitors, Monoclonal antibody medications 32. increase in this compound creates characteristic tough skin appearance with reduced elasticity 35. Malignant plasma cells 36. Immune response initiated by T cells 37. Seen in patients with B12 deficiency sometimes; numbness or tingling 42. Gout 44. One disease causing malabsorption; may lead to deficiencies 45. Electrolyte imbalance noted in Tumor lysis syndrome; requires kayexelate or medication "cocktail" to address 46. surgery to reduce tear loss in Sjogren's 47. Coating with slimy/sticky stuff for easier cellular feasting 48. Severe combined immunodeficiency disease 49. Born in the marrow, grow in the marrow 50. Weight loss, diaphoresis, fatigue

Down 2. Bone marrow issue: too many cells, abnormal functions; don't do their jobs properly 3. Antigen to antibody clumping for cellular feasting 4. Joint disease starting near smaller joints of the extremities; "swan's neck" 5. Exposure to disease or vaccine; moderated by body response for immunity 6. Baby erythrocyte 8. System less likely affected by folate but more by B12 deficiency? 9. Core sample taken of cellular matrix within bones to determine functional level and health 13. Platelet numbers of 50000 rather than normal level of 150-450000 per microliter 14. Immune response primarily mediated by B cells and antibodies 18. Hallmark symptom of SLE 19. One of the antihistamines; useful for premedication, or to prevent or mitigate mild hypersensitivity reactions 23. Immunity that is given via temporary measure: IVIG, or through mother to baby 24. Don't forget to check this when assessing for anemia! 25. Joint disease usually targeting the lower back and pelvis 29. Acute and systemic hypersensitive reaction; Severe Type I reaction 30. Most common anemia worldwide, any age group 31. Essential to absorb B12 for use 33. Born in the marrow, grow in the thymus 34. For blood products and IVIG, this is helpful to prevent milder hypersensitivity reactions; give 30 minutes prior to prodedure 38. Better to give this to a patient with neutropenia than a raw fruit. 39. Chemotherapy to induce remission in leukemic patients 40. When cells burst, this syndrome results 41. Sickle cell, thallassemia are this type of anemia 43. Physical and chemical barriers to invasion: skin, tears, gastric juices; immunity type 44. Syndrome of Scleroderma