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Across 2. Extracellular signaling molecules produced by other cells which binds to trasmembrane receptors triggering intracellular signaling responses (2 Words) 5. Serine/threonine protein kinase which is activated in response to DNA damage and is recruited to the damaged region 7. Cells containing two slightly different copies of each chromsome, one from each parent 11. Mitogens interact with cell surface receptors to trigger ___________ ____________ (2 words). (2 Words) 12. The last step of the cell cycle which divides the cytoplasm 13. Inter-homolog connections that play a crucial role in holding homologs together 14. Repetitive DNA sequences and associated proteins found at the end of linear chromosomes; it is a nongenomic template that is used for their synthesis 16. Cells that accumulate sever DNA damage typically undergo this process 18. Cell inhibitor protein which interacts with and inhibits Mdm2 22. Chk1/Chk2 activity is important for blocking entry into this phase (2 Words) 24. Negative regulators of E2F proteins (bind to E2F in the absence of mitogens) (2 words) (2 Words) 25. The structure beneath the plasma membrane which is responsible for forming the cleavage furrow and which generates the force necessary for cellular division (2 words) (2 Words) 26. Eggs and sperm 28. Cells carrying only a single copy of each chromosome 29. Key gene regulatory protein controlled by the MAP kinase cascade; it functions to promote entry into the cell cycle by increasing the expression of G1 cyclins 31. Stimulates fibroblasts, smooth muscle cells and neuroglial cells to divide (abbr.)

Down 1. A small GTPase of teh Ras superfamily that controls the assembly and function of the contractile ring at the site of cleavage 3. Why cells can undergo a limited number of cell divisions; cells are in a non-dividing state which they cannot exit (3 words) (3 Words) 4. Enzyme responsible for generating telomere sequence 6. The midbody contains remnants of these interpolar microtubules of the spindle midzone (2 words) (2 Words) 8. Assembles just before mitosis and marks the site where the cell wall will assemble and divide the cell in two (2 words) (2 Words) 9. Sexual reproduction depends on this nuclear division process 10. This is the first visible change of cytokinesis in an animal cell (2 words) (2 Words) 15. Found in higher plant cells and is composted of microtubules from the mitotic spindle 17. Cell with multiple nuclei within the same cytoplasm 19. This is what it is called when homologs fail to separate properly during meiosis 20. Function to stimulate cell division by relieving negative regulatory controls 21. This is the stage when the contractile ring forms 23. Process occuring during early prophase I in which the homologs begin to associate along their length 27. Formed up the termination of cleavage and is visualized as a thin strand of cytoplasm that connects the two daughter cells 30. Mitogen that acts on epidermal, epithelial and non-epithelial cells (abbr.)