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Across 2. Type of immunity 5. The "M" in M cell 6. Macs and PMNs mainly deal with this 9. Term for propensity to mount IgE response to allergens 11. Inverts flagellin genes 12. Complexes that activate C' via classical pathway 13. Main Ab isotype in Type-I allergy response 14. HIV-1 and 2 are both this 16. Etiologic agent of AIDS 17. Type IV hypersensitivity reactions involve this 20. 84 known types of this 22. Anti-viral therapies target this 26. Direct isotype switching 28. Autoimmunity does not contain this classification 29. Not a late phase response but this 31. Type of memory after infection 33. Most important type of immunity 35. Provide artificial passive immunization 40. Acts as a hapten 41. Cell that secrets Ab

Down 1. Transports IgG across placenta 3. Coats their cells with human proteins 4. Lymphocytes migrate into LN by this 7. Mutation that leads to leukocyte adhesion deficiency 8. Repeated infections suggest this 10. Inhalation of allergen leads to this 15. Increases blood flow and permeability 18. Number of hypersensitivity "types" 19. Too small for IR 21. Injection with this will control systemic anaphylaxis 23. Skin allergy occurs as this 24. Expresses one surface Ag 25. Polysaccharide is bound to tetanus toxoid this way 27. Cause massive release of cytokines 30. One of the factors in m.o. infectivity 32. Type of T-independent Ag 34. Kill via ADCC 36. Differentiates into a plasma cell 37. Composition of HIV genome 38. Enables phagocytes to destroy opsonized pathogen 39. Coined the term "hapten"