| 18,000BP | | Quaker migration from n.Midlands to PA |
| 15,000BP? | | farming begin in Mexico |
| 13-14,000BP | | first Paleo-Indians arrive in NA? |
| 13,000BP | | Clovis point big game hunters arrive in NA |
| 13,000BP | | Reconquista completed |
| 12,900BP | | Viking colony in Newfoundland |
| 10,000BP? | | Cortez conquers Mexico; smallpox decimates native population |
| 9000BP? | | Puritan migration from East Anglia to MA |
| 7000BP? | | Santa Fe founded |
| 6000BP? | | bow and arrow reaches NA |
| 5000BP | | Daniel Boone lays Wilderness road through Cumberland Gap |
| 4000BP | | Declaration of Independence |
| 3000BP | | brown rat reaches US |
| 10th century AD | | first black slaves brought to New World (Hispanola) |
| 1100 | | arrival of Inuit (Eskimos) in NA |
| 15th century AD | | Jamestown founded |
| 1492 | | "Pennsylvania Dutch" migrate to PA |
| 1492 | | Seven Years (French and Indian) War |
| 1501 | | Yonker Dryas abrupt climate change episode |
| 1519 | | De Soto expedition through the Southeast |
| 1519-22 | | first mounds of the "Moundbuilders" |
| 1521 | | Peak of last Ice Age, Followed by warming |
| 1538-43 | | Breton,British, and Potuguese fishermen off the coast of ne. NA |
| 1540-42 | | invasion of a few Eurasian megafauna |
| 1565 | | agriculture spreads to Mississippi Valley, or is independently invented there |
| 1607 | | "Scotch-Irish" migration from England/Scotland border to PA and then to Applachain |
| 1609 | | James Watt invents steam engine, Official start of the Industrial Rvolution, in England |
| 1621 | | Magellan expedition's voyage around the world |
| 1624-64 | | Cavlier and servant migration from SSW England to VA |
| 1629-40 | | first mission settlements in California |
| 1638-55 | | New Netherlands |
| 1642-75 | | Pilgrims come ashore in Massachusetts |
| 1675-1725 | | War of Independence |
| 1680 | | agriculture spreads to Southwestern US |
| 1707 | | New Sweden |
| 1718-75 | | founding of St. Augustine, the first permanent European colony in present US territory |
| 1749-54 | | Boston Tea Party |
| 1754-63 | | Philadelphia Yearly Meeting abolishes slavery first case of abolition in the Western world |
| 1758 | | Pueblo revolt |
| 1765 | | unification of England and Scotland creates Great Britain |
| 1769 | | Coronado expedition to Southwest, introduction of the horse to the great plains |
| 1774 | | Nadene speakers arrive in NA |
| 1775 | | Cahokia's ppulation peaks at about 25-43000 |
| 1775-1781 | | Ponce de Leon tries to colonize Florida |
| 1776 | | Clovis points no longer manufactured. Folsom points, for buffalo hunting, manufactured |
| 1776 | | Columbus reaches bahamas, Cuba, and Hispanola |
