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Across 8. ____ hypermutation 11. Th2: worm and ___ antigen 13. Type 3 hypersensitivity 14. gp120, _____ protein 15. Process makes the antigen more desirable to a macrophage 20. Dendritic cell covered in Fc receptors 22. Increases blood flow and blood vessel permeability 24. Th1: bacterial and ___ antigen 26. _______ viruses are no longer capable of causing disease in humans after being passed through several other species 29. T cell attacks tissue graft 32. Stop, drop, and roll proteins 33. This therapy is contraindicated for transplants 39. Most common type of chronic inflammation 41. Beta cells killed in this disease 42. Innate cascade 43. They don't care who they get their electrons from 44. Accopanies cDNA into nucleus 46. Like student's before the quarter begins, B cells do this (2 words) 47. Leaves you feeling itchy

Down 1. hormone of the immune system 2. Stores energy and contains macrophages 3. Born with it, non-specific 4. Type of antibody test 5. Found in tears 6. T cell matures here 7. IgA gut structure 8. ____ antigens bind outside the MHC 9. Involved in antigen presentation 10. Live to eat 12. IgA is found in 16. Makes you all hot and bothered 17. Cells that secrete antibodies 18. Cellular trafficking 19. Found on eosinophils and mast cells 21. Hey Tcell, this is dangerous! 23. _____ cells are terminated in the bone marrow 25. First on the scene, first to die 27. Two vesicles fuse and denature DNA 28. Poke holes in everything, but self (2 words) 30. Only __ antigen presenting cells can express costimulatory signals 31. NK hole poking protein 34. Get me outta this vessel! 35. parasites beware of this immunoglobulin 36. Describes IgM's structure 37. IgG is known to cross the____ 38. What's in the bun? 40. You'd be living in a bubble without it 45. Means you have allergies to just about everything